Several substances and medications may interact with Aciphex (Rabeprazole), potentially affecting its effectiveness or causing adverse reactions. It's crucial to inform your healthcare provider about all the drugs, supplements, and substances you are currently taking. Here are some common interactions to be aware of:
Other Medications: Some drugs can interact with Aciphex, altering its absorption or metabolism. For example, certain antifungal medications, like ketoconazole and itraconazole, and antiviral drugs, such as atazanavir and nelfinavir, may interfere with Rabeprazole's effectiveness.
Blood Thinners: Medications like warfarin, which are used as blood thinners, may have their effects enhanced when taken with Aciphex. This can increase the risk of bleeding.
Antiretroviral Medications: Some drugs used to treat HIV, like rilpivirine, can interact with Rabeprazole, potentially reducing its effectiveness.
Clopidogrel: There have been concerns about potential interactions between clopidogrel (Plavix) and PPIs like Aciphex, which may affect how clopidogrel works. If you are taking both medications, it's important to discuss this with your healthcare provider.
Iron Supplements: Taking iron supplements may reduce the absorption of Rabeprazole. To avoid this interaction, it's advisable to take the iron supplements at least 2 hours apart from Aciphex.
Methotrexate: Methotrexate, commonly used to treat conditions like rheumatoid arthritis and psoriasis, may have its effectiveness reduced when taken with Aciphex. Healthcare providers may adjust the dosage or monitor your response if you are prescribed both medications.
Food and Drinks: Aciphex can be taken with or without food. However, certain foods and beverages, especially those that are acidic or spicy, may exacerbate acid-related conditions and affect the medication's effectiveness.
Alcohol: Excessive alcohol consumption can irritate the stomach lining, making it counterproductive to the effects of Aciphex. Reducing alcohol intake or avoiding it while on this medication may be advisable.
It's essential to consult with your healthcare provider regarding potential interactions and to provide them with a complete list of all substances and medications you are currently taking. They can offer guidance on managing these interactions, which may include adjusting dosages, changing medications, or monitoring for potential side effects.
