Pristiq (Desvenlafaxine)

What is Generic Pristiq?

Action of the drug Pristiq explained by its properties which has been proven in experimental studies.

• It increases the spontaneous activity of pyramidal cells of the hippocampus and accelerates their recovery after functional inhibition;
• It increases the reuptake of serotonin by neurons of the cerebral cortex and hippocampus.

Clinical studies show that the drug affects:

• Changes in mood, occupying an intermediate position between sedative antidepressants and stimulating ones of bipolar classification;
• Somatic effects associated with anxiety and mood swings;
• The nature and behavior disorders in alcoholics during abstinence.

Moreover, Pristiq does not affect:

• Sleep and attention;
• Cardiovascular system;
• Cholinergic system (no anticholinergic symptoms).

It does not lead to addiction, quickly and completely absorbed.

Rapidly distributed in the body, binding to plasma proteins is about 94%. Metabolize extensively in the liver by beta-oxidation and N-demethylation.

The half-life is 2.5 hours and is excreted, the main part as metabolites and 8% in unchanged form.

Clinical studies have demonstrated that pharmacokinetic parameters of Pristiq remain practically unchanged even in the presence of liver cirrhosis in patients with chronic alcoholism. And it inhibits serotonin norepinephrine in the ratio 10: 1.

In what kind of disease treatment Pristiq is helpful?

It is helpful in the treatment of minor, moderate or serious depressions.

What should I tell my health care provider before I take Generic Pristiq?

• Children up to 15 years.
• Concomitant use of MAO inhibitors.
• Pregnancy and lactation.

How should I take Pristiq?

Tablets containing Venlafaxine with a quick release are encouraged to take with meals, preferably at the same time.

Dosage information

It is appointed for adults in the form of tablets of 50 and 100 mg. If to speak about the tablet with the lowest dozation it is usually recommended therapeutic dose taking in two or three stages: morning, afternoon and evening.

For elderly patients and patients with severe renal insufficiency dose of 1 or 2 tablets per day in two divided doses.

People with chronic alcoholism do not require dose adjustment.

The duration of course depends on the severity and course of the disease and it is not allowed to take more than 7 tablets. Dose escalation carried out not often than every 14 days. Doctors usually advise taking these pills for another half a year after the course.
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What may interact with Pristiq?

Concomitant use of Pristiq with MAO inhibitors is contraindicated.

Concomitant use of non-selective MAO inhibitors may cause collapse, increased blood pressure and body temperature, convulsions and even death.

What should I watch for while taking Pristiq?

In depression patients should be under medical supervision, especially early in treatment.

If a patient uses Pristiq plans to carry out general anesthesia then the anesthesiologist should notify the use of Pristiq and cancel its application for 24-48 hours prior to surgery. The necessity of urgent surgical intervention the operation can be carried out without prior withdrawal of the drug under strict medical supervision during it.

In the transition from MAO inhibitors for the drug you must do a two-week break between discontinuation of MAO inhibitor and the start of the drug. In the opposite case of transition you should make a 24-hour break between cessation of the drug and the beginning of the use of MAO inhibitors.

Canceling the drug is made in accordance with the general principles of discontinuation of antidepressants, namely: to reduce the dose gradually within 7-14 days.

Some patients may experience reduction in attention. Drivers and operators of machinery must take into account the possibility of drowsiness when using the drug.

Avoid abrupt discontinuation of Venlafaxine. So after cessation of treatment encouraged gradually reducing the dose within 1 - 2 weeks to reduce the risk of withdrawal symptoms. If after a dose reduction or suspension of treatment intolerance symptoms arise, you should consider returning to a previously assigned dose. In the future, your doctor may reduce the dose to continue, but more slowly.

What side effects may I notice from Generic Pristiq?

Adverse effects are rare.

From the gastrointestinal tract: epigastric pain and abdominal pain, dry mouth, anorexia, nausea, vomiting, constipation, flatulence.

From CNS: insomnia, drowsiness, terrible dreams, fatigue, dizziness, headache, tremor, redness of the face.

From the cardiovascular system: tachycardia, extrasystoles, pain in the region of the heart.

From the respiratory system: respiratory discomfort, feeling of "lump" in the throat.

Other: muscle pain, back pain.

In case of overdose the stomach should be washed and should be monitored the cardiovascular system, metabolic indices and renal function. If necessary - a symptomatic therapy, mechanical ventilation and adjustment disorders of renal function and metabolism.

Where can I keep Pristiq?

Keep the drug away from little kids in a dry and dark place at a temperature about twenty five degrees.