Crestor is a very helpful medication which is used to control excess cholesterol. It helps to halt the development of atherosclerosis in patients as well as primary prevention of major cardiovascular complications. Its active component Rosuvastatin refers to statins of the last IV generation. It reduces chronic inflammation and stimulates the production of nitric oxide, a relaxing artery. This is called pleiotropic (additional) effects. It was also conducted a study that showed that the benefit of the drug outweighs this potential harm because it may increase the risk of developing diabetes. And it is scientifically proven that people who took placebo died more often than those who took this drug.
Also, medication Crestor is prescribed to adolescents suffering from hereditary hypercholesterolemia. This medicine or other statins doctors prescribe if diet and physical activity do not help enough. During treatment, the patient should follow a diet and maintain physical activity. This drug should be discontinued only if side effects become intolerable. Statins sometimes cause pain in the muscles, disturbances in thinking and memory, digestive disorders. These problems can be similar to age-related disorders. The results of blood tests for ALT and AST may worsen, but this does not mean that the liver is broken.
Crestor during pregnancy as well as other statins is contraindicated. There is evidence that this drug negatively affects the development of the fetus, increases the risk of deviations in newborns. Women of reproductive age who take statins should carefully use effective methods of contraception. If there was an unplanned pregnancy, the taking of tablets from cholesterol is immediately stopped. Do I need to lower cholesterol? This dispute lasts for decades. It has been shown that dyslipidemia plays a leading role in the pathogenesis of atherosclerosis and, in particular, an increase in the level of low-density lipoprotein cholesterol. Most doctors are well aware of non-pharmacological methods of prophylaxis and atherosclerosis treatment with Crestor. These include controlling blood levels, weight, diet, as possible, Mediterranean, dosage physical activity, rejection of bad habits, especially from smoking. An important condition for the implementation of these activities is the partnership of the doctor and the patient, his conscientiousness and adherence to treatment, which is achieved by explaining to the patient the role of risk factors in reducing the duration of his life. After all, who else will teach the patient how to protect their health?
The use of Crestor has made it possible to achieve the target level in most patients compared to other statins. It should be emphasized that in accordance with the new recommendations for reducing cholesterol, a similar category of patients (group 1: individuals with clinical manifestations of atherosclerosis), intensive therapy with high doses of Crestor (20-40 mg) is also recommended, with the expected decrease of level by 50%. Lower lipophilicity and practically no metabolism by the cytochrome P450 enzyme system without significant involvement of the 3A4 isoenzyme cause a low risk of drug interactions, which allows taking Crestor in combination with most other drugs, including those mentioned above. In addition, the possibility to use this drug in smaller doses, as a more powerful hypolipidemic preparation, reduces the likelihood of side effects, the risk of development of which depends more on the dose of the drug.
For many years, two drugs for reducing cholesterol dominated in the world pharmaceutical market. The first is Lipitor, the second - Crestor. The first was more popular until 2011when it lost its patent protection, because of what the sales of the drug began to fall gradually. And now you ask, does this mean that Crestor cleared his way and became the best-selling statins on the market? I will answer you - not exactly. After Lipitor lost his exclusivity in the market, consumers, patients and doctors began to think about whether to replace itss reception with its cheaper version - generics. And many have done so. Also after 2016, Crestor generic was also produced. This drug entered the top-10 bestsellers of the world. Obviously, the use of the original drug would not raise doubts about the effectiveness of treatment. However, the cost of such treatment cannot be called available for most patients, for whom the price of the drug often determines adherence to treatment. Therefore, the use of quality generic with proven bioequivalence will make treatment as effective as the original drug, but much more affordable, which will increase adherence to the treatment of patients. Also it is important that you can buy Crestor almost in every country because it is one of the famous medication that is used all over the world and you can even buy it in Spain online pharmacies or other country of Europe and other continents. The presence of a full range of doses makes it possible to select a more individual treatment for each patient, that is, to choose a more effective and at the same time safe dose. Since the effectiveness of standard Crestor dosage is well known and sufficiently studied, I would like to pay more attention to new doses of 10 mg and 20 mg. At the same time, a dose of 30 mg (if to take two pills) is especially interesting when aggressive statin therapy is necessary (ACS, failure to achieve the target with a dose of 20 mg), since doctors rarely use the dose of 40 mg for fear of adverse side effects, and 20 doses Mg in many cases is inadequate.
