Savella (Milnacipran)

What is Generic Savella?

Savella relates to new type antidepressants. This type inhibits the reuptake of serotonin and norepinephrine, which may have an advantage over similar drugs that affect only one of them.

It is a selective inhibitor of monoamine reuptake.

It is not endowed with sedation and does not affect negatively on cognitive function.

It is quite independent of the regime and diet. The plasma Cmax is fixed two hours after ingestion.

In few days of continuous use there is stability.

It is biotransformed with the method conjugation with glucuronic acid.

Pharmacologically active metabolites do not possess.

T1/2 is 8 hours. 90% excreted by the kidneys. In few days leaves the body entirely.

In what kind of disease treatment Savella is helpful?

Savella is appointed in therapy of clinical depression of moderate and severe degrees of severity. The drug also has a positive effect in the treatment of pain syndromes, such as fibromyalgia.

What should I tell my health care provider before I take Generic Savella?

The drug Savella has contraindications:

Absolute:

• Hypersensitivity to the drug substance;
• The age under 15 years;
• Simultaneous administration with selective and nonselective MAO inhibitors type B.

Relative:

• Obstruction of the urinary tract;
• Hyperplasia of the prostate (benign);
• Co-administration of digoxin, MAO inhibitors type A;
• Pregnancy;
• Lactation period.

Used with caution during serious illnesses. Inform you physician about every of them that you currently have or had in history.

How should I take Savella?

The drug is indicated inside in the first half the day in 2 divided doses during meals.

Dosage information

Usually it is taken 50 mg two times a day. Patients with kidney disease smaller dose may be assigned.

Medium dose is 100 mg. Possible to increase the dosage to 250 mg per day. In renal insufficiency the dose is reduced focusing on the results of analyzes.

After successful completion of the course of depressive disorder the patient can be assigned to a maintenance dose for few months to prevent recurrence. Prohibited withdrawal abrupt of the drug since it normally causes undesirable symptoms.

What may interact with Savella?

In co-administered drug with other agents are observed:

• Probable serotonergic syndrome with MAO inhibitors;
• Hypertensive crisis or cardiac arrhythmias with Epinephrine and Norepinephrine;
• Inhibition of the hypotensive effect of Clonidine;
• Possible potentiation of hemodynamic disorders with Digoxin.

What should I watch for while taking Savella?

Savella does not adversely affect the sexual activity of the patient (in contrast to other drugs with the same action). Also, the drug does not cause problems with the cardiovascular system, as with other antidepressants (e.g., tricyclic).

Taking of this medication should not coincide with the reception of other antidepressants (especially monoamine oxidase inhibitors) because this may cause abnormally high levels of serotonin in the brain. Serotonin intoxication is a potentially life-threatening condition. For the same reason an overdose of drugs SNRIs may also be life-threatening.

Don't take Savella during pregnancy because it crosses the placental barrier, and the data on its impact on the fetus is absent.

Caution should be exercised in people with cardiomyopathy, hypertension and seizures. In order to reduce possible side effects dosage of Savella, if necessary, increase gradually. It is excluded to take medication if you drive a car and other complex mechanisms and to consume alcohol.

What side effects may I notice from Generic Savella?

If to compare with the other drugs it causes less serious side effects. Among the side effects are most common:

CNS:

• dizziness;
• sense of anxiety;
• headache;
• tremor.

Digestive System:

• constipation;
• nausea;
• dry mouth;
• an increase of transaminases in a moderate form.

Other:

• difficulty in urinating;
• hot flushes;
• increased sweating;
• serotonin syndrome;
• itching;
• vertigo;
• shiver;
• testicular pain.

Generally the side effects are rare and usually during the 14 days of the course; are not particularly pronounced; cropped independently.

In the case of minor drug overdose occur:

• constipation;
• sweating.

When exceeding 800-1000 mg:

• tachycardia;
• labored breathing;
• vomiting.

In the high dose, exactly in 1900-2800 mg are occurred all the above listed.

It should be done in such case: gastric lavage and symptomatic treatment. Within a day condition of the patient is recommended to be monitored. There is no specific antidote.

Where can I keep Savella?

Keep Savella in a place with the following conditions: dry, dark (out of reach of sunlight), away from little children and at the temperature below thirty degrees.
You can purchase generic Savella online at legitimate and trusted online pharmacy (France).