Paxil (Paroxetine)

What is Generic Paxil?

Paxil has an international non-proprietary name Paroxetine according to the name of active ingredient. This drug is in modern medicine, the most popular, because the positive effect on the body, removing the stress, tension, fear and phobias that often build up in connection with the a pretty fast life rhythm, or in severe conditions of human work. Among the antidepressants it is highly effective in the fight against depressions of completely different etiology.

Paxil belongs to the drugs with a powerful effect on the human body. The mechanism of this effect is the inhibition of the reuptake of the serotonin by the brain neurons which in other words is called "the hormone of happiness."

In contrast, for example, from other drugs it does not inhibit the CNS of the patient and hypertension attacks.

In addition, the main feature of this product is that it does not affect cardiac function, and even the electrocardiogram parameters and frequency of contractions of the heart muscle.

This drug is highly effective in all types of depression and relapses which can greatly complicate the treatment of disease.

In what kind of disease treatment Paxil is helpful?

The indications for appointment and the use of this drug are the following condition and the patient's disease:

• Depression of any kind, severity and etiology;
• OCD (neurotic states, which have in their basics possession and obsession of any idea);
• Panic disorders, agoraphobia, or fear of open spaces;
• Social phobia (almost all types);
• generalized anxiety disorders, that is mental disorders without a specific object, circumstances or conditions that are characterized by a fairly persistent state of anxiety;
• Post-traumatic stress disorder.

What should I tell my health care provider before I take Generic Paxil?

Results of the tests of the drug were given basis on the excretion contraindications for the appointment and the use of Paxil. Thus, the drug is not administered in the following cases:

• If you are hypersensitive to the constituent components of the preparation;
• Together with some drugs which belong to the group of monoamine oxidase inhibitors such as Nialamide, Selegine and Sonapax or Thioridazine;
• During pregnancy and breastfeeding;
• In children up to the age of eighteen.

How should I take Paxil?

Paxil usually in all cases of diseases and disorders is assigned one tablet once a day preferably with breakfast in the morning.

Dosage information

Thus, in the depressions of different kinds and the etiology daily dosage of medication would be 20 mg.

After two - three weeks of treatment with this medication doctor should evaluate the degree of effectiveness of the drug and the whole therapy and in the case of absence of bright effect to increase the dosage to a maximum - 50 mg. However, increasing the dosage should be performed by adding once a week an initial dose of 10 mg drug (half tablets).

In OCD it assigned promptly at a dosage 40 mg and for adjusting, if necessary, the dosage may be increased to 60 mg.

The same dosage can be assigned for panic disorders. But nevertheless the initial dosage should not exceed 10 mg per day with gradually increasing to 40 mg depending on the effectiveness.

In other ailments generally use 20 mg dosages - the first two weeks and gradually increasing to 50 mg.

What may interact with Paxil?

Paxil should not be taken simultaneously with MAO inhibitors and tryptophan, as this combination can lead to a so-called serotonin syndrome that is increase the level of serotonin concentration in the interneuronal space. Furthermore, Tryptophan increases the frequency and amplifies the intensity of headaches, nausea, sweating.

That syndrome can also occur in the combination therapy with Tramodol, Lithium and SSRIs type of antidepressants.

Paxil is able to enhance the impact of alcohol-containing products, reduce the level of effectiveness of Tamoxifen and Digoxin.

Activity of Paroxine amplified at simultaneous its reception with Cimetidine and inhibitors of microsomal oxidation.

Increased bleeding can occur in the joint application of the drug with indirect coagulants and antithrombotic drugs. The activity of the drug can be reduced also with inducers of microsomal oxidation.

It is necessary to adjust the dosage in cases of co-administration of the drug with Propafenone, Procyclidine, Metoprolol, Thioridazine, Tricyclic antidepressants, Perphenazine, Flecainide and Codeine.

It is allowed simultaneous intake of this drug with drugs and anticonvulsants.

Serotonin syndrome may be manifested by the following symptoms:

• Fever;
• Excessive muscle tone and involuntary their startle;
• Strong emotional arousal, until a delirium tremens.

What should I watch for while taking Paxil?

Since it belongs to the group of antidepressants this drug can cause and reverse reactions such as suicidal thoughts, hostility in adolescents up to eighteen years. Therefore this drug is not administered in childhood and adolescence.

In the period of treatment with this drug patients should be especially careful during work related to the potential danger to the patient's life such as driving a car or work with complex mechanisms and machines.

What side effects may I notice from Generic Paxil?

Acceptance of this drug may be associated with adverse reactions of the body such as:

• violation of appetite;
• the appearance of the hematoma on the skin and mucous membranes;
• an increase cholesterol levels in the blood;
• excitement;
• somnological state, that is developing insomnia and sleepiness, nightmares during sleep;
• headaches and dizziness;
• lethargy;
• hallucinations;
• dilation of the pupils, blurred vision;
• cardiopalmus;
• rash;
• yawn;
• nausea, constipation or diarrhea, sialoschesis, ie dyspeptic condition;
• decreased libido;
• cutaneous rash;
• patient’s gain weight.

Also receiving Paxil is characterized by such a state as a withdrawal. Which means that in its abolition can cause such reactions as: tinnitus, sleep disturbances, nausea, rash, paresthesia, dizziness, anxiety. These symptoms usually do not have a bright intensity and passed through a short term independently.

However, due to the risk of expression of negative effects it is important to stop taking this medication gradually, not abruptly interrupting the course.

Paxil has a fairly wide therapeutic range. In this regard, the level of risk of the overdosing is practically reduced to zero although not completely eliminated. An overdose can also occur through the above described symptoms and complemented by an increase in blood pressure and a feverish state.

As an antidote to the medication does not exist then the treatment of an overdose state should be carried out depending on the level of manifestation of symptoms.

Where can I keep Paxil?

Keep the drug in a place with the following requirements: dry, dark, at a room temperature (about twenty five degrees) and far away from children.