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Product name: Generic Inspra

Category: Cardiovascular Diseases, Hypertension, Disease

Active Ingredient: Eplerenone

Manufacturer: Lupin Limited

Status: Checked

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Price per pill: $1.39

What is Generic Inspra?

People suffering from chronic heart failure are often prescribed various diuretics. One such is Inspra. It is a potassium-sparing agent that effectively removes all excess fluid from the body, and also removes puffiness, prevents loss of the microelement, potassium, important for the normal functioning of the heart muscle.
With a sufficiently long use of the drug, there is a significant decrease in the mortality rate from different cardiovascular diseases and the frequency of hospitalization, if necessary, for their treatment.

In what kind of disease treatment Inspra is helpful?

The indications for taking this medication are as follows:
• Myocardial infarction. It is used as a component of standard treatment to reduce overall mortality, unforeseen cardiac death, and a significant reduction in repeated hospitalizations in people after myocardial infarction accompanied by left ventricular dysfunction.
• Chronic heart failure. The drug is a component of conventional treatment, starting with the II functional class of chronic heart failure in combination with ACE inhibitors, as well as beta-adrenoblockers to reduce cardiovascular mortality associated with the rapid progression of chronic heart failure due to a sharp decrease in the left ventricular ejection fraction.

What should I tell my health care provider before I take Generic Inspra?

It is not recommended to take the drug Inspra if there is:
clinically significant hyperkalemia;
increased potassium content in blood serum;
moderate or severe renal failure;
a markedly elevated serum creatinine concentration;
severe hepatic impairment;
simultaneous administration of diuretics, potassium preparations, as well as strong inhibitors of the CYP3A4 group;
rare hereditary diseases;
the age is less than eighteen years;
hypersensitivity to the components that make up the tablets.
With special care, it is necessary to take the drug with such diagnoses:
type 2 diabetes mellitus;
microalbuminuria;
simultaneous use of eplerenone, ACE inhibitors and other drugs aimed at maintaining the level of potassium in the blood plasma.
Also patients who prefer to buy Generic Inspra online should read carefully an instruction.

How should I take Inspra?

The medicine is available in the form of diamond-shaped tablets covered with a filmy coating of a yellowish hue. Inspra medication can be used regardless of food intake. The duration of treatment is determined by the severity, as well as the course of the disease.

Dosage information

In heart failure, resulting from the patient's transfer of myocardial infarction, the recommended initial dose is 50 mg once a day. Therapy should be started with a dose of 25 mg once a day, and then the dose should be titrated in order to reach the required rate - 50 mg once a day for a month.
For elderly people to use it is not necessary to change the initial dose. This also applies to patients suffering from a mild and moderate liver dysfunction.

What may interact with Generic Inspra?

1. Potassium-sparing diuretics, as well as preparations containing potassium in combination with these tablets, increase the risk of hyperkalemia. Therefore, eplerenone is forbidden to prescribe to people who take potassium-sparing diuretics and potassium medicines to prevent the increase in the effect of antihypertensive medications and other diuretics.
2. Preparations that contain lithium, when interacting with Inspra, can cause intoxication with this microelement due to an increase in its concentration in the blood plasma.
3. Ciclosporin and Tacrolimus in some cases cause a violation of kidney function, and also lead to an increased risk of hyperkalemia.
4. Therapy with combined use of NSAIDs can cause acute renal failure in the patient, which can be explained by direct suppression of glomerular filtration.
5. Trimethoprim simultaneously with these tablets increases the risk of hyperkalemia, especially in elderly patients.
6. ACE inhibitors together with different antagonists of angiotensin II receptors should be taken with extreme caution because it causes an increased risk of developing hyperkalemia.
7. Alfa1-adrenoblockers in combination with eplerenone may increase the hypotensive effect or increase the risk of developing orthostatic hypotension.
8. Tricyclic antidepressants, neuroleptics: when these drugs are used together with eplerenone, the antihypertensive effect may increase or the risk of orthostatic hypotension may increase.
9. Glucocorticoids with Inspra can cause a delay in sodium, as well as liquid.
10. To date, there are no results of clinically significant pharmacokinetic interaction of Warfarin with this medication is not revealed. Therefore, care must be taken with combination therapy.
11. When using Inspra with preparations that inhibit CYP3A4, a fairly strong pharmacokinetic interaction is possible. Typically, an inhibitor of CYP3A4 leads to an increase in AUC eplerenone almost fourfold. The simultaneous use with various inhibitors of CYP3A4 is contraindicated.

What should I watch for while taking Inspra?

Women during pregnancy should be prescribed medication with caution and only when the intended benefit to the mother significantly exceeds the possible risk to the child. There may be undesirable effects of eplerenone on newborns who are breastfeeding, therefore it is recommended either to interrupt breastfeeding, or to cancel taking the medication, depending on the degree of its importance for the woman.

What side effects may I notice from Generic Inspra?

Possible manifestation of various Inspra side effects:
eosinophilia;
hypercholesteremia;
hyperkalemia;
hypertriglyceridemia;
hyponatremia;
dehydration;
hypothyroidism;
fainting and frequent dizziness;
severe headaches;
hypesesia;
insomnia;
significant lowering of blood pressure;
atrial fibrillation;
orthostatic hypotension;
left ventricular failure;
thrombosis of the arteries on the legs;
pharyngitis;
acute cough;
diarrhea with constipation;
cholecystitis;
nausea with vomiting;
meteorisms;
increased sweating;
severe itching;
cramps in the muscles of the lower limbs;
musculoskeletal pain;
pain in the back area.

Where can I keep Inspra?

The medicine should be stored out of reach of small children at an air temperature of 15-30 ° C. Shelf life of the drug is 3 years. Also it is possible to buy Inspra without prescription in a lot of international pharmacies like Spain online pharmacy.
Active Ingredient: Eplerenone
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