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Aygestin (Norethisterone Bp)

Product name: Aygestin (Norethisterone Bp)

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Active Ingredient:Norethisterone Bp

Manufacturer: Ind-Swift

Status: Checked

What is Generic Aygestin?The active ingredient of Aygestin is a Norethisterone. In comparison with other known progestins drug even though it does..
  • Aygestin (Norethisterone Bp):5mg × 30 pills, 5mg × 60 pills, 5mg × 90 pills, 5mg × 120 pills, 5mg × 180 pills
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Brand: Ind-Swift

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  • Product Code:   Aygestin (Norethisterone Bp)

What is Generic Aygestin?

The active ingredient of Aygestin is a Norethisterone. In comparison with other known progestins drug even though it does not belong to the most active progestogens, yet its properties are unusually favorable for therapy.

In the so-called "delay of mensis" (postponing of menstruation) which is used to determine the effectiveness of progestogens; the drug exhibits the properties of weak progestogen.

In contrast to many progestin compounds Norethisterone has a pronounced anti-estrogenic character and unlike to the other Norethisterone derivatives in the body only a small part of the compound is converted to estrogen.

At the same time under the action of the active substance were observed gynecomastia in men and in women breast enlargement. Besides the main progestin action it was also identified weak androgenic compound property. According to clinical and pharmacological studies Norethisterone blocks production of follicle stimulating hormone (FSH) and corpus luteum hormone (LH), reduces the synthesis of steroids by the corpus luteum.

Norethisterone has mainly progestin property shows significant anti-estrogenic and minimal estrogenic and androgenic effect may be widely applied in the area of obstetrics and gynecology.

Aygestin is well absorbed oral progestin drug that within 1-2 hours reaches its maximum plasma concentration. 24 hours after administration of 1 mg of Norethisterone main indicator in the plasma level is 0.2 mg / 1 ml. According to research 1 hour after receiving Aygestin maximum radioactivity observed in the endometrium and thyroid.

Norethisterone rather quickly excreted from the body. Isotopic studies show that 50-70% of the compound is released in urine, and 20-40% in the feces.

In what kind of disease treatment Aygestin is helpful?

Premenstrual syndrome, mammalgia, cycle disorders that are accompanied by a shortening of the period of secretion, dysfunctional uterine bleeding, cystic glandular hyperplasia of the endometrium, endometriosis, adenomyosis, termination and prevention of lactation, a delay of menstruation, menopause, in the case of individual need oral contraception, dysmenorrhea, algomenoreya, amenorrheamyoma, endometrial cancer, mastopathy, infertility, miscarriage, diagnostic progesterone test.

What should I tell my health care provider before I take Generic Aygestin?

Usually your physician choose the drug which will be suitable for you because he took into account your history of illnesses but you should know about all conditions that are incompatible with Aygestin:

  • During puberty;
  • Breast cancer (including suspected);
  • Malignant tumors of female genital mutilation;
  • Pregnancy (including suspected, except for applications regarding miscarriage);
  • Jaundice (including history);
  • Acute liver disease (including benign and malignant tumors);
  • Altered liver function and kidney;
  • Hyperbilirubinemia;
  • The tendency to thrombosis;
  • Acute thrombophlebitis or thromboembolism;
  • Bleeding of the urinary tract of unknown origin;
  • Bleeding from the genital tract of unknown origin;
  • Cholestatic jaundice or of pregnant women or pruritus in history;
  • Obesity;
  • Herpes;
  • Hypersensitivity to the drug.

Precautions: asthma, chronic heart failure, epilepsy, hypertension, migraine, renal failure, convulsions or other CNS disorders (including history).

How should I take Aygestin?

Aygestin is taken internally with a glass of water with or without food at certain days of menstrual cycle.

Dosage information

In uterine myoma: 5 - 10 mg, from 5 to 25 days of the menstrual cycle, not more than 6 months.

Mammalgia, premenstrual syndrome, dysmenorrhea: 5 - 10 mg per day in the period from 16th to 25th day of the menstrual cycle and can be taken together with an estrogen; in the lack of effectiveness and severe decompensated form - 5 mg, starting from the fifth day of the cycle for 21 days.

Endometriosis: 5 mg per day, from 5 to 25 day cycle for 6 months; continuation of therapy is determined by the doctor.

Adenomyosis: 5 mg per day from the fifth to the 25th day of the cycle for 6 months, or starting from 2.5 mg per day on the fifth day of the cycle, gradually increase the dose to 2.5 mg every 2 - 3 weeks for 4 - 6 months.

Termination of dysfunctional uterine bleeding: 5 - 10 mg for 6 - 12 days, relapse prevention - to 5 - 10 mg per day from the 16th to the 25th day of the cycle.

Endometrial hyperplasia, anovulatory metrorrhagia: not more than 6 months before the treatment, the dysfunctional nature of the bleeding must be confirmed by histological analysis; 5 - 10 mg daily for 6 - 12 days; in achieving the desired effect, between 16 and 25 days cycle 5 - 10 mg per day, usually in conjunction with estrogen, for the prevention of relapse.

Progesterone Diagnostic test: 10 mg for 10 days; if after 3 - 7 days after application of of Aygestin appeared moderate bloody discharge and remained for 3 - 4 days, the reaction is considered to be a natural.

Lactation termination: the first three days administered as a daily dose of 20 mg from fourth to seventh day, take 15 mg per day from the eighth to the tenth day taking 10 mg per day.

In case of other diagnosis you should consult with a doctor about the dosage.

What may interact with Aygestin?

Be wary appointed in conjunction with hypoglycemic drugs, oral anticoagulants and corticosteroids. It is not recommended combination with barbiturates, Phenytoin, Rifampin, Cimetidine and others affecting microsomal oxidation in the liver.

When used together with inducers of hepatic microsomal enzymes, especially cytochrome P450 enzymes such as anticonvulsant drugs, anti-infective drugs, aminoglutethimide, hydantoins and other is possible acceleration of metabolism of Aygestin, reduced plasma concentrations, reducing its action and the changing nature of uterine bleeding. Herbal preparations which include St. John's wort can stimulate the metabolism of Aygestin.

What should I watch for while taking Aygestin?

If the patient has forgotten to take the next tablet, the missed tablet should be taken as soon as possible and in this case it is necessary to use additional methods of contraception. Before treatment you should exclude the presence of malignant tumors.

What side effects may I notice from Generic Aygestin?

From the digestive system: dyspeptic symptoms (nausea, vomiting).

From endocrine system: uterine bleeding, acyclic bloody discharge from the vagina, weight gain, breast engorgement.

From a metabolism: peripheral edema.

From the CNS and peripheral nervous system: paresthesia, fatigue (does not require additional treatment).

Dermatological reactions: chloasma, melasma, allergic reactions (rash, pruritus).

With prolonged use: thrombosis, thromboembolism.

Where can I keep Aygestin?

Keep Aygestin in a dry, dark place, away from the children at a room temperature. You can also purchase generic Aygestin online.

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Aygestin (Norethisterone Bp)
5mg × 30 pills, 5mg × 60 pills, 5mg × 90 pills, 5mg × 120 pills, 5mg × 180 pills
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Aygestin (Norethisterone Bp)

Tags: Norethisterone Bp