Combining 100mg of sertraline with 10mg of escitalopram as adjunct therapies is generally not recommended due to the risk of serotonin syndrome, a potentially serious condition caused by excessive serotonin activity in the body. Both sertraline and escitalopram are selective serotonin reuptake inhibitors (SSRIs) that increase serotonin levels in the brain. When used together, especially at higher doses, they can lead to an accumulation of serotonin, resulting in symptoms ranging from mild (such as shivering and diarrhea) to severe (like high fever, seizures, and even death in extreme cases).
While there may be clinical situations where a doctor decides to prescribe both medications together, such decisions are usually made cautiously and with careful monitoring for any signs of serotonin syndrome. Factors such as the individual's overall health, tolerance to medications, and specific symptoms being treated are taken into consideration.
If you are considering or have been prescribed both sertraline and escitalopram together, it is crucial to follow your doctor's instructions closely and report any unusual symptoms immediately. Your doctor may adjust the doses, monitor your response closely, and provide guidance on managing potential side effects or interactions. Never adjust your medication regimen without consulting your healthcare provider first, as they can provide personalized advice based on your medical history and current condition.