Actos (Pioglitazone) can interact with several medications and substances, potentially affecting how it works or increasing the risk of side effects. It's important to inform your healthcare provider about all medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
Some medications that may interact with Actos include:
Insulin or other diabetes medications: Using Actos in combination with insulin or other diabetes medications may increase the risk of hypoglycemia (low blood sugar). Your doctor may need to adjust the dosage of these medications to avoid this complication.
Gemfibrozil: This medication used to lower cholesterol levels can increase the concentration of Actos in the blood, potentially increasing the risk of side effects.
Rifampin: An antibiotic used to treat tuberculosis and other infections, rifampin can decrease the effectiveness of Actos.
Birth control pills: Actos may interact with hormonal contraceptives, reducing their effectiveness in preventing pregnancy. Discuss alternative methods of contraception with your doctor if necessary.
Certain heart medications: Drugs such as nifedipine or diltiazem, used to treat high blood pressure or angina, can interact with Actos, requiring careful monitoring and possible adjustments in dosage.
Certain antifungal medications: Ketoconazole and fluconazole, used to treat fungal infections, can interact with Actos, requiring adjustments in dosage or monitoring for side effects.
Certain medications affecting liver enzymes: Drugs that affect liver enzymes, such as CYP2C8 inhibitors or inducers, can impact how Actos is metabolized in the body. Examples include fluvoxamine (inhibitor) and rifampin (inducer).
Additionally, alcohol consumption can interact with Actos, potentially increasing the risk of liver problems.
To avoid interactions, it's crucial to inform your healthcare provider about all medications and substances you are taking before starting Actos. Your doctor can evaluate potential interactions and adjust your treatment plan accordingly to ensure your safety and the effectiveness of Actos in managing your type 2 diabetes.