Long-term use of Losartan, particularly at a dose of 50mg combined with potassium, can lead to a variety of side effects. Common long-term side effects include dizziness or lightheadedness due to its blood pressure-lowering effects. Some patients may experience increased levels of potassium in the blood, known as hyperkalemia, which can lead to serious complications such as irregular heartbeats. Kidney function can also be affected over time, potentially leading to renal impairment or worsening of pre-existing kidney conditions.
There is also a risk of developing angioedema, a severe allergic reaction that can cause swelling of the face, lips, throat, and potentially the airways, which may require immediate medical attention. Gastrointestinal issues, such as abdominal pain, nausea, or diarrhea, may persist or worsen with long-term use. While less common, some patients might experience muscle cramps, fatigue, or changes in mood, including depression or anxiety.
Regular monitoring by a healthcare professional is crucial when taking Losartan long-term to manage these potential side effects and ensure that the medication continues to be safe and effective for the patient. Blood pressure, kidney function, and electrolyte levels, particularly potassium, should be routinely checked to mitigate any adverse effects and adjust the treatment as necessary. It is important for patients to report any new or worsening symptoms to their healthcare provider promptly.