It's generally not advisable to take trazodone and doxepin close together due to their potential interactions and overlapping effects on the central nervous system. Both medications are antidepressants that affect serotonin levels, albeit through different mechanisms. Trazodone primarily works by blocking serotonin receptors and inhibiting serotonin reuptake, while doxepin acts by inhibiting the reuptake of serotonin and norepinephrine.
Taking these medications together or in close succession can increase the risk of serotonin syndrome, a potentially serious condition characterized by symptoms such as agitation, confusion, rapid heart rate, high blood pressure, sweating, tremors, and in severe cases, seizures and coma. Serotonin syndrome can occur when there is an excessive accumulation of serotonin in the body, typically due to interactions between medications that affect serotonin levels.
If your healthcare provider has prescribed both trazodone and doxepin, they will typically advise on a dosing schedule that minimizes the risk of adverse effects. It's important to follow their instructions closely and to report any unusual symptoms or side effects promptly. If you have concerns about the timing of your medications or their interactions, consulting with your healthcare provider or pharmacist is recommended to ensure safe and effective use of these antidepressants.