Neoral (Cyclosporine)

What is Generic Neoral?

This substance is used in the prophylactic treatment of transplant rejection after transplantation of human tissue or organs. This may be donor kidneys or lungs, bone marrow, liver or heart. Considered agent has a pronounced immunosuppressive activity which affects the security mechanisms in the body and thus prolongs the life of various allogeneic transplants. Feature of Generic Neoral is that it is sufficiently selective and at the same time reversibly alters lymphocyte work namely inhibits the formation and secretion of lymphokines and then binds to specific receptors on the individual.

In what kind of disease treatment Neoral is helpful?

• Immunosuppression after surgery bone marrow transplantation, kidney transplantation, and other important organs;
• A high degree of activity in rheumatoid arthritis in drug resistance to basic treatment;
• Severe forms of atopic dermatitis and psoriasis, when standard therapy shows inefficiency;
• Nephrotic syndrome due to glomerular vascular pathology.
• To the intensity of the production of tear fluid.

What should I tell my health care provider before I take Generic Neoral?

Inform your doctor about your state condition before you purchase Generic Neoral online and especially about:

• Hypersensitivity to certain components of the drug, both effective and support, to polyoxyethylated castor oil in the composition of dosage forms;
• Precancerous skin diseases;
• Against the background of malignant tumors;
• Up to 1 year;
• In lactation period;
• Hepatic or renal failure;
• Varicella, recently transferred or current;
• Viral infections (Varicella zoster including) because of the likelihood of generalization process;
• Hyperkalemia;
• Hypertension;
• Malabsorption syndrome.

How should I take Neoral?

Reviews of Generic Neoral say that it should be taken internally.

Dosage information

In organ transplantation therapy starts in 3-12 hours before the time for which the operation is scheduled. When it comes to transplant materials such as bone marrow then the initial dose is administered the day before (24 hours before) operation. Generally, intravenous injection is carried out during two weeks. Next there is an oral maintenance therapy. As this medicine has serious toxic effects equally on the kidneys and the liver, the optimum use of it comes down to a balanced tolerated dosage that does not cause serious damage to vital organs. The first dose is 3-5 mg / kg per day and when there comes the turn of ingestion - 10-15 mg / kg. In the future, the attending physician will determine the dosage taking into account the concentration of drug in the blood.

What may interact with Generic Neoral?

Is increased the likelihood of development while taking Generic Neoral:

• Hyperkalemia in case of simultaneous application with the drugs potassium or potassium-sparing diuretics;
• Nephrotoxicity - in the case of simultaneous reception with amphotericin B, antibiotics, aminoglycoside, colchicine, ciprofloxacin;
• Side effects of kidney - with NSAIDs;
• Possible muscle pain and weakness - with colchicine and lovastatin;
• Renal dysfunction - while the use of diuretics;
• An increase in toxicity and an increase in the blood plasma concentration of doxorubicin at reception with doxorubicin;
• Hypertension and nephrotoxicity, the increase in the blood concentration of cyclosporine IN plasma when taken with methotrexate;
• Severe renal insufficiency when taken with melphalan;
• Increasing toxicity, increase in T1 / 2, a decrease in clearance of teniposide when taken with it;
• Decrease of the effectiveness of warfarin, and cyclosporin when taken with warfarin;
• Acute renal failure while taking enalapril;
• Strengthening of gingival hyperplasia when taken with nifedipine;
• A increase in the bioavailability of diclofenac in patients receiving cyclosporine with the possible development of a reversible functional disorders of the kidneys;
• Reduced clearance of prednisolone, may increase at higher doses of cyclosporin blood concentration;
• Concentration of cyclosporine in the blood increases methylprednisolone;
• Possible increase in Cmax of cyclosporine in the blood plasma and absorption rate when taking cisapride;
• May decrease the clearance of colchicine, digoxin, simvastatin, lovastatin, pravastatin, prednisolone, which will increase the toxic effects;
• Cyclosporine nephrotoxicity increases antivirals, ACE inhibitors, antibiotics, cephalosporin, aminoglycosides, co-trimoxazole, trimethoprim, ciprofloxacin;
• May increase the effects of theophylline and its derivatives, quinidine and its derivatives;
• May be increased concentration of cyclosporine at reception imipinema in combination with cilastatin, which in turn causes neurotoxicity symptoms;
• Probability of lymphoproliferative disorders and developing infections when taken with other immunosuppressants.

What should I watch for while taking Neoral?

To avoid symptoms of side effects of Generic Neoral and achieve maximum effectiveness in the treatment of drug it is necessary to adhere strictly the course prescribed by the attending specialist.

You should follow the relevant instructions:

• The need for systematic monitoring of the functional state of the kidneys and liver;
• Blood pressure control;
• Establishing of lipid concentrations in the serum;
• Generic Neoral dose is reduced by increasing the concentration of bilirubin, creatinine, urea, liver enzymes in the blood;
• Antihypertensive treatment is necessary in the development of hypertension;
• Is required a dose reduction and / or turn to special diets with increasing serum lipids;
• Excessive immunosuppression should be avoided;
• Do not carry out in the course of therapy vaccination with attenuated live vaccines against measles, mumps, polio and rubella;
• Undesirable simultaneous use with the drug cyclosporine lipid-lowering drugs.

If you buy Generic Neoral without prescription then you should read the instruction in the package.

What side effects may I notice from Generic Neoral?

• Disturbance to the functioning of the liver / kidney, gingival hypertrophy;
• Tremors and numbness in the extremities;
• Diarrhea, nausea, vomiting;
• Hyper concentration of uric acid in plasma, menstrual disorders or lack thereof;
• Convulsions, enhanced susceptibility to infection.

Where can I keep Neoral?

The drug should be stored in a dry place at a room temperature. Do not let kids play with it. Also you can buy Generic Neoral online.