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Product name: Effexor Xr (Venlafaxine)
What is Generic Effexor Xr?
It is a drug that belongs to antidepressants available as capsules for internal reception of prolonged action. Trade name drugs - Effexor Xr. International name is Venlafaxine which also is an active ingredient. The pharmacological action is the inhibition of serotonin and norepinephrine, as well as the influence of the weak inhibiting dopamine reuptake.
Actions associated with the ability of the drug to enhance the transmission of nerve impulses in the CNS processes. According to indexes of inhibition serotonin reuptake Venlafaxine is second in selective inhibition of serotonin reuptake.
Drugs with similar effects are often prescribed to different groups of patients. Sometimes users report high efficiency of it by which most of them have an excellent outcome.
In what kind of disease treatmentEffexor Xr is helpful?
Reviews of positive character Effexor Xr gets when administered to patients who suffer from depressive disorders. It is appointed to use the drug in the prevention of relapse and treatment of depressive state. Due to the fact that the drug can have serious side effects, the purpose of treatment and the choice of receiving dosages should only be performed by the attending specialist who is familiar with the patient's medical history.
What should I tell my health care provider before I takeGeneric Effexor Xr?
It is strictly forbidden appointment and use of Effexor Xr in the manifestation of any of the following symptoms and contraindications:
- Hypersensitivity to the active substance or to any of its ingredients;
- Children younger than 18 years;
- During breastfeeding;
- The simultaneous use of MAO inhibitors as well as 7 days after their withdrawal, including the simultaneous use with drugs used to treat obesity.
Be careful in the appointment in unstable angina, hypertension, myocardial infarction, seizures, angle-closure glaucoma, suicidal tendencies, hyponatremia and tendency to bleeding.
How should I take Effexor Xr?
The tablets are taken by mouth, without chewing during a meal.
It is produced in the form of capsules of 37.5 and 75 mg of active substance in each of them. The instructions to the drug indicated that at the initial stage of treatment patients received a low dose that is taken daily 2 times. When for several weeks condition does not improve, the daily dose is doubled and in that way the dosage selected and is performed until a desired therapeutic effect.
Begin intake with a dose of 37.5 mg twice a day. The dose may be increased to 75 mg / day once a week.
In depression -225 mg / day for 3 doses, with severe depression - 375 mg in 3 divided doses.
Cancellation of a drug is performed gradually over 2 weeks and more than 75 mg per week. The daily dose is reduced by 50% with hepatic and renal failure. In order to avoid adverse effects on the use of Venlafaxine instructions must be strictly observed.
However, there are limits of acceptable biggest dose, which must be observed. After reaching the treatment results begin to gradually reduce the dose to a certain effective level.
What may interact with Effexor Xr?
Use with Clozapine is also accompanied with an increase in the blood concentration and the appearance of undesirable effects.
It is noted amplification effects of haloperidol.
Admission of Venlafaxine should be started 2 weeks after treatment with MAO inhibitors.
When taken with CYP3A4 inhibitors (Voriconazole, Posaconazole, Atazanavir, Clarithromycin, Nelfinavir, Ritonavir, Itraconazole, Saquinavir), the concentration of the drug is increased.
Cimetidine inhibits the metabolism and reduces the clearance of the active ingredient. When taken with Warfarin is amplified its anticoagulant effect.
Agents acting on serotonergic transmission (Sibutramine, Tramadol, drugs Li +), causing the risk of serotonin syndrome so it is necessary to reduce the dose of both drugs. Use with ethanol is contraindicated.
What should I watch for while taking Effexor Xr?
More frequent are reports of adverse reactions, and there are no connection between dose and severity of adverse reactions. In some individuals, those reactions were manifested at a dose of 37.5 mg, and some patients are well tolerated with the dose of 150 mg.
To achieve the desired result you need to adhere strictly to the prescribed treatment, the dosage and regular contact with the attending physician. If everything is done correctly then usually a manifestation of side effects goes almost painless for the patient and the therapeutic effect is faster and become more stable.
What side effects may I notice from Generic Effexor Xr?
When using Effexor Xr may manifest certain side effects, including:
- bleeding from mucous membranes;
- bleeding from the gastrointestinal tract;
- body mass reduction;
- violations of liver function tests;
- a manifestation of apathy;
- decreased libido;
- abnormal dreams;
- increased muscle tone;
- sleep disturbances;
- violation of taste perception;
- weakness, fatigue;
- decreased appetite, vomiting, constipation, dry mouth;
- increase the level of cholesterol;
- hypertension, tachycardia;
- insomnia, nervousness, paraesthesia, tremor;
- accommodation disturbances, mydriasis;
- skin rash, erythema multiforme.
After the abrupt cancellation are observed: fatigue, drowsiness, dizziness, nausea, anorexia, dry mouth, insomnia, anxiety, irritability and hypomania. In this connection it is recommended to reduce a dose gradually.
Overdose usually occurs while taking alcohol or psychotropic drugs. Manifested symptoms are: sleepiness up to coma, diarrhea, dizziness, tremors, decreased or increased blood pressure, convulsive state, ventricular tachycardia, ECG changes.
There are a high percentage of deaths in overdose.
There is no specific antidote. Treatment consists of gastric lavage (do not induce vomiting!), a reception of sorbents, administration of these drugs to maintain blood circulation and respiration.
You can buy Effexor Xr online without prescription.
Where can I keepEffexor Xr?
Keep Effexor Xr in a dry clean place at room temperature, away from little children; do not let them play with a package.
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