Celexa (Citalopram Hydrobromide)

What is Generic Celexa?

Celexa is a potent inhibitor of the reuptake of serotonin and its reducing effect in the case of long-term treatment with this active ingredient is not happening.

The ability to bind with receptors including adrenergic receptors, histamine, muscarinic in Generic Celexa is weakly expressed. It inhibits cytochrome P450IID6 in a fairly small extent and therefore does not interact with drugs directly metabolized by this enzyme.

It helps to improve mood, suppresses anxiety, eliminates dysphoria, weakens the feeling of tension and fear, relieves compulsive and almost doesn’t cause a soporific effect.

The highest concentration of active ingredient in the blood after ingestion occurs within 3-4 hours. The bioavailability is close to 80%. Binding with plasma proteins is 80%.

In the blood it is present mainly in its original form. The half-life time is one and half days. Evacuate with urine and through the intestines.

In what kind of disease treatment Celexa is helpful?

This medication is indicated for use in the following cases:

• OCD;
• Anxiety-depressive disorders;
• Panic disorder;
• Depression of different genesis;
• Affective disorders;
• Psychosomatic diseases with concomitant autonomic dysfunction;
• Somatization disorder;
• Vascular dementia;
• Depression caused by alcohol dependence;
• Problems with eating, in females and in older people.

What should I tell my health care provider before I take Generic Celexa?

There are some cases in which you shouldn’t use Celexa:

• Hypersensitivity;
• Condition with symptoms of serotonin syndrome;
• Concomitant use of pimozide;
• Combined use with MAO inhibitors in the case of cancellation - two weeks after stop taking them.

How should I take Celexa?

Instructions for use of Celexa recommends to take the drug internally once a day without regard to food reception at any time but it is necessary to drink water with it. After the start of the antidepressant therapy an effect can be expected no earlier than in two weeks. Therapy should be continued until the disappearance of symptoms within six months.

Celexa Dosage information

Cancelling the drug should be performed slowly, gradually reducing the dose over 2-3 weeks.

Usually people take twenty mg but it can be increased to 40 mg per day but not more than 60 mg.

In panic disorders it is 10 mg per day. After a week of treatment it can be increased to 20 mg per day. If an effect of treatment is unsatisfactory then the dosage can be increased to 60 mg per day. The therapeutic effect is usually reached after about 3 months of therapy.

The elderly patients can take 20 mg but depending upon the severity of condition and individual sensitivity it may be increased in this category of patients to 40 mg but it is the biggest dose they can take.

Do not abruptly discontinue therapy. The dose should be successively reduced by several weeks in order to reduce the risk of undesirable symptoms.

What may interact with Celexa?

In a joint application with MAO blocker is not excluded occurrence of hypertensive crisis (malignant serotonin syndrome). Using drug Citalopram with those blockers and during two weeks after their withdrawal is forbidden.

It inhibits CYP2D6 isoenzyme in a very small degree so it does not interact perfectly with drugs metabolized by this isoenzyme directly.

Action of Sumatriptan and other drugs of serotonergic group are stimulated by online Celexa in their joint application.

Pharmacodynamic interactions with cardiotropic agents are not detected during clinical trials.

What should I watch for while taking Celexa?

After 7-10 days of continuous use is developing lasting clinical effect.

There is no confirmed evidence of the safety of Celexa use during pregnancy. The use is justified when the potential benefits of conducted therapy to mother is much higher than the perceived risk to the fetus.

Any teratogenic effects in experimental studies have not been identified as well as the effect of the active substances on reproduction and fetal development.

What side effects may I notice from Generic Celexa?

Reception of Celexa can cause the following consequences:

CNS:

• headache;
• dizziness;
• drowsiness;
• tremor;
• migraine;
• excitation;
• concern;
• anxiety:
• insomnia;
• nervousness;
• sleep disturbance;
• paresthesia;
• amnesia;
• impaired concentration;
• decreased libido;
• apathy;
• anorexia;
• increased appetite;
• asthenia;
• suicide attempts;
• mood changes;
• confusion of thought;
• emotional lability;
• aggressive behavior;
• mania;
• agitation;
• panic behavior;
• hypomania;
• psychosis;
• paranoid reaction;
• extrapyramidal disorders;
• excessive fatigue;
• euphoria;
• hallucinations;
• serotonin syndrome;
• depersonalization;
• convulsions;
• seizures - when taken in high doses.

Digestive System:

• nausea;
• constipation;
• abdominal pain;
• diarrhea;
• vomiting;
• dyspepsia;
• dry mouth;
• flatulence;
• increased activity of liver enzymes;
• excessive salivation.

Urinary system:

• polyuria;
• frequent urination.

Metabolic disorders:

• hyperthermia;
• hyponatremia;
• increase or decrease in weight.

Respiratory System:

• dyspnea;
• cough;
• sinusitis;
• rhinitis.

Reproductive System:

• impotence;
• dysmenorrhea;
• female anorgasmia;
• galactorrhea;
• disruptions of the menstrual cycle;
• decreased or increased libido;
• ejaculation disorders.

Skin:

• itching;
• rash;
• epidermal necrolysis;
• increased sweating;
• angioedema;
• photosensitivity.

Special Senses:

• mydriasis;
• blurred vision and accommodation;
• noise in ears;
• taste disturbance.

Musculoskeletal system:

• arthralgia;
• myalgia.

Blood coagulation:

• thrombocytopenia;
• development of bleeding - rarely.

Other:

• fainting;
• asthenia;
• allergic reactions;
• fatigue;
• mammalgia;
• yawn;
• malaise;
• anaphylactoid reactions;
• gnashing of teeth.

Symptoms of overdose: coma, drowsiness, stupor, increasing of the QT interval, seizures, ventricular arrhythmia, cyanosis, vomiting, nausea, perspiration, convulsions, hyperventilation. It is possible the emergence of signs of serotonin syndrome.

Therapy of overdose must be maintaining and symptomatic, include use of laxatives and enterosorbents, gastric lavage. In disorders of consciousness of the patient is advised to intubate. It is necessary to monitor the ECG and basic life functions. Spastic syndrome treated with diazepam. The increase in the QRS complex on the ECG can be normalized by administration of hypertonic sodium chloride solution.

Where can I keep Celexa?

Keep a package of Celexa in a dry and dark place at a temperature about twenty five degrees. Don’t let your children play with this drug! You can also buy Celexa online without prescription.